Facebook Twitter LinkedIn

Home No. 14: Why the need for a quarantine if mice are known to be healthy?

Jun 28

No. 14: Why the need for a quarantine if mice are known to be healthy?

Posted by: admin in

Tagged in: Untagged 

Sign Up to receive free weekly articles like these

Research Compliance

Why the need for a quarantine if mice are known to be healthy?

Reader Question: I am collaborating with an investigator at another university who wants to send me some mice that can be bred here at my university. They are free of diseases like my mice here, but I've learned they must go through a six-week quarantine. That will seriously delay our research. Why this quarantine if the mice are healthy?

Expert comments: The majority of rodents used for research are specific pathogen-free (SPF). Unfortunately, there is no written rule as to what the “specific” pathogens are to be, and thus they will vary from institution to institution. Although you understand these new mice to be “free of diseases,” they may not be free of the same diseases as the animals currently housed at your university.

Based on the chosen excluded pathogens, most institutions have an approved vendor and a non-approved vendor list from which investigators can order animals. Animals from the approved vendor are known to be free of all the institution’s excluded pathogens and can typically be ordered directly into the animal facility. But animals from a non-approved vendor either have an unknown health status or a known excluded pathogen and are required to go through a quarantine period.

It is quite common for the non-approved vendor list to include facilities that are composed of predominantly experimental units, such as universities. This is because the risk of introducing micro-organisms into experimental units is greater due to diverse populations of personnel, shared equipment, and, in general, increased movement of animals and people. It is much more challenging to control pathogen exposure and transmission in this setting.

Additionally, transgenic animals from academic institutions are an increased risk because they have the possibility of being immunodeficient due to their genetic manipulation. As such, they may shed a micro-organism longer than other animals or may be persistently infected where other animals would typically clear the infection.

With regard to quarantine, personnel access should be minimized. Some facilities do allow limited access to carry out minimal procedures, such as breeding and/or genotyping. Check with your institution regarding what can and cannot be done while your animals are in quarantine.

While it may seem inconvenient that these new animals must go through quarantine, remember that it is essentially a safety mechanism. The purpose of quarantine is to protect the health of the research animals at your institution, including your existing colony.

Expert comments by Laura Gallaugher, DVM, clinical laboratory-animal veterinarian, University Laboratory Animal Resources, and assistant professor of preventive medicine, The Ohio State University.

Comments (7)
written by Charles Miller, July 09, 2010
Our vets allow mice that are in quarantine to be used for genotyping, breeding, and other purposes while they are being checked out for viruses and other diseases. Mice are simply held in isolation in a separate area of the vivarium in a negative pressure room with air filtration. The cages and other materials leaving the room are autoclaved, entry into the room is through a separate route, etc., so there is little chance of introducing an organism into the main mouse colonies.
harlan quarantine
written by redarts, July 10, 2010
Our vet requires mice and rats acquired from Harlan or Charles River for example to undergo a 10 day quarantine. We feel this is extraneous. Are there any rules about quarantine time for vendor acquired rodents?
written by David E. Harrison, July 11, 2010
There is a grave danger that lab animals will be exposed to pathogens while they are being shipped. Many vendors ship using commercial shippers, who are notorious for employees that are grossly careless with materials being shipped, including your lab animals! They may well damage the barrier to pathogens in the shipping box, AND pack your lab animals with others that carry serious pathogens. Unless lab animals are shipped from door to door under the control of experts in avoiding pathogens, you should treat them as contaminated no matter how clean their institution of origin.
written by yiwu tiles, June 03, 2011
And that narrow promotional Plastic Crafts vision really blanketed the whole game. promotional Leather Crafts
written by wholesaler, June 03, 2011
Not only could I not figure out how to level up my character or manage my ship from within the ship itself, promotional Metal Crafts
written by wholesaler, June 03, 2011
so you make a list of the skills you want a person to have, china wholesalers which is now your “job description.” from China
written by promotional Leather Crafts, June 03, 2011
The game's just not designed from a captain's perspective. promotional Pottery & Enamel I have orders, but how can I follow them,

Write comment
smaller | bigger

Write the displayed characters