Principal Investigators Association

Revising and Resubmitting an NIH Grant: Deciding Between A1 and A0

Revising and Resubmitting
an NIH Grant: Deciding
Between A1 and A0

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Presenter: John W. Ludlow, Ph.D
Webinar Date: Thursday, June 19, 2014, 2pm ET (11am PT)

Length: 60 minutes

Winning an NIH grant, besides being difficult, requires a lot of time and effort. It is not uncommon for an investigator to take several months to write the proposal, while simultaneously collecting and publishing pilot data before actually submitting the grant to the NIH for merit review. After merit review, provided the proposal has a score which ranks it high enough, it will go through a second level of review at the Institute or Center that it was initially submitted through. At this stage of the process, a decision to fund or reject the project will be made. Given the large number of proposals received, the nature of the review process, and funding limits, the number of grants chosen for funding during each cycle is small. Award data for the NIH as a whole reveals that approximately 90 percent of submitted application are not funded.

This must-attend Webinar has been designed to provide tips and strategies to improve your chances of being awarded funds after resubmitting your initial proposal. While focusing primarily on the R01 mechanism, the information presented can be applied to virtually all other NIH grant types. Since 2009, NIH only allows investigators to submit a particular proposal twice, once as a new submission (A0) and one resubmission (A1). One option which has always been open to investigators after the rejection of an A1 resubmission is to substantially revise the content and scope of the project in order to be eligible for submission as a new application. Beginning in April of 2014, there is a new policy whereby researchers have an additional option to submit the same idea contained in the rejected A1 as an A0 application for the next appropriate due date. Details of this new policy, how it may shape your thinking whether to submit your revised application as A1 or A0, and strategies for the revision itself, will be presented.

5 Key Take-Aways:

  • The success rate for resubmitted proposals
    has historically been higher than for first-time
  • With the new resubmission policy change,
    unless you would like the opportunity to
    address reviewer comments directly, you
    do not have to resubmit as an A1.
  • NIH will not assess the similarity of the science
    in the new application to any previously reviewed
    submission when accepting an application for
  • NIH’s policy for accepting overlapping
    applications still remains in effect - duplicate
    or highly overlapping applications under
    review at the same time is not allowed.
  • Your options if the proposal is turned down
    again or is just below the pay line.

Who Should Attend:

  • Any principal investigator, post-doctoral fellow, graduate student who has already submitted an NIH grant application or is considering to do so. This includes scientists in academia or employed by a small business which is eligible for federal funding.



John W. Ludlow, Ph.D, began his academic faculty career at the University of Rochester (NY) in 1991, with appointments in the department of biochemistry at the medical school and the university’s cancer research center. During this time he maintained an independently funded research laboratory training graduate students and post doctoral fellows in the area of tumor suppressor gene expression, protein structure, and function. Funding for his laboratory came from a variety of sources, including the NIH, the American Cancer Society, and private foundations. Dr. Ludlow began working in the commercial biotechnology sector in 2000, developing and managing research and pre-clinical programs for cell therapy and tissue engineered products, where he has continued to compete in, and advise on, multiple NIH award programs.

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This Webinar presentation is brought to you as a training tool by the Principal Investigators Association, which is an independent organization. The presentation, tools presented and their contents are not connected with the National Institutes of Health (NIH), nor are they endorsed by this agency. All views expressed are those personally held by the presenter and are not official government policies or opinions.


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